AGTRAP

Protein-coding gene in the species Homo sapiens
AGTRAP
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1ZV0, 4YAY

Identifiers
AliasesAGTRAP, ATRAP, angiotensin II receptor associated protein
External IDsOMIM: 608729; MGI: 1339977; HomoloGene: 7621; GeneCards: AGTRAP; OMA:AGTRAP - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for AGTRAP
Genomic location for AGTRAP
Band1p36.22Start11,736,084 bp[1]
End11,754,802 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for AGTRAP
Genomic location for AGTRAP
Band4 E1|4 78.67 cMStart148,161,518 bp[2]
End148,172,488 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • right uterine tube

  • pancreatic ductal cell

  • blood

  • gastric mucosa

  • spleen

  • right lung

  • upper lobe of left lung

  • bone marrow
Top expressed in
  • blastocyst

  • right kidney

  • granulocyte

  • choroid plexus of fourth ventricle

  • proximal tubule

  • gastrula

  • Ileal epithelium

  • yolk sac

  • human kidney

  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • angiotensin type II receptor activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • plasma membrane
  • Golgi apparatus
  • cell cortex
  • endoplasmic reticulum membrane
  • cytoplasmic vesicle membrane
  • intracellular membrane-bounded organelle
  • endoplasmic reticulum
  • membrane
  • cytoplasmic vesicle
  • nucleoplasm
  • cytosol
Biological process
  • regulation of blood pressure
  • angiotensin-activated signaling pathway
  • response to hypoxia
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57085

11610

Ensembl

ENSG00000177674

ENSMUSG00000029007

UniProt

Q6RW13

Q9WVK0

RefSeq (mRNA)

NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350

NM_001301281
NM_009642

RefSeq (protein)

NP_001035284
NP_001035285
NP_001035286
NP_001035287
NP_065083

NP_001288210
NP_033772

Location (UCSC)Chr 1: 11.74 – 11.75 MbChr 4: 148.16 – 148.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.[5][6]

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.[6]

Interactions

AGTRAP has been shown to interact with GNB2L1.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177674 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029007 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (Dec 2001). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol. 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.
  6. ^ a b "Entrez Gene: AGTRAP angiotensin II receptor-associated protein".

External links

Further reading

  • Daviet L, Lehtonen JY, Tamura K, et al. (1999). "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor". J. Biol. Chem. 274 (24): 17058–62. doi:10.1074/jbc.274.24.17058. PMID 10358057.
  • Cui T, Nakagami H, Iwai M, et al. (2001). "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth". Biochem. Biophys. Res. Commun. 279 (3): 938–41. doi:10.1006/bbrc.2000.4055. PMID 11162453.
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ (2004). "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling". Mol. Biol. Cell. 14 (12): 5038–50. doi:10.1091/mbc.E03-06-0383. PMC 284805. PMID 12960423.
  • Guo DF, Chenier I, Tardif V, et al. (2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane". Biochem. Biophys. Res. Commun. 310 (4): 1254–65. doi:10.1016/j.bbrc.2003.09.154. PMID 14559250.
  • Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. doi:10.1074/jbc.M401544200. PMID 14985364.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation". J. Biol. Chem. 280 (13): 12536–41. doi:10.1074/jbc.M500296200. PMID 15668245.
  • Tanaka Y, Tamura K, Koide Y, et al. (2005). "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy". FEBS Lett. 579 (7): 1579–86. doi:10.1016/j.febslet.2005.01.068. PMID 15757644. S2CID 36456303.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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