AP1G1

Protein-coding gene in the species Homo sapiens
AP1G1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1IU1

Identifiers
AliasesAP1G1, ADTG, CLAPG1, adaptor related protein complex 1 gamma 1 subunit, adaptor related protein complex 1 subunit gamma 1, USRISD
External IDsOMIM: 603533; MGI: 101919; HomoloGene: 47995; GeneCards: AP1G1; OMA:AP1G1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for AP1G1
Genomic location for AP1G1
Band16q22.2Start71,729,000 bp[1]
End71,809,201 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for AP1G1
Genomic location for AP1G1
Band8 D3|8 57.26 cMStart110,505,186 bp[2]
End110,590,836 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • Achilles tendon

  • epithelium of colon

  • sperm

  • corpus epididymis

  • islet of Langerhans

  • sural nerve

  • left testis

  • middle temporal gyrus

  • right testis
Top expressed in
  • genital tubercle

  • tail of embryo

  • cumulus cell

  • granulocyte

  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • Paneth cell

  • ventricular zone

  • spermatocyte

  • right kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transporter activity
  • GTP-dependent protein binding
  • protein binding
  • kinesin binding
Cellular component
  • recycling endosome
  • clathrin-coated endocytic vesicle membrane
  • Golgi apparatus
  • trans-Golgi network membrane
  • membrane
  • intracellular membrane-bounded organelle
  • Golgi membrane
  • lysosomal membrane
  • AP-type membrane coat adaptor complex
  • clathrin-coated vesicle membrane
  • membrane coat
  • cytoplasmic vesicle membrane
  • cytoplasmic vesicle
  • clathrin-coated vesicle
  • clathrin adaptor complex
  • cytoplasm
  • cytosol
  • AP-1 adaptor complex
Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • mitigation of host defenses by virus
  • Golgi to lysosome transport
  • positive regulation of natural killer cell degranulation
  • melanosome organization
  • endosome to melanosome transport
  • protein transport
  • intracellular protein transport
  • positive regulation of natural killer cell mediated cytotoxicity
  • vesicle-mediated transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

164

11765

Ensembl

ENSG00000166747

ENSMUSG00000031731

UniProt

O43747

P22892

RefSeq (mRNA)

NM_001128
NM_001030007

NM_001301211
NM_009677

RefSeq (protein)

NP_001025178
NP_001119

NP_001288140
NP_033807

Location (UCSC)Chr 16: 71.73 – 71.81 MbChr 8: 110.51 – 110.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.[5][6]

Function

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

AP1G1 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166747 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031731 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (Jun 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
  6. ^ a b c Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Sep 1998). "Identification and characterization of novel clathrin adaptor-related proteins". The Journal of Biological Chemistry. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
  7. ^ "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit".
  8. ^ a b c Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi:10.1016/s0092-8674(00)81650-5. PMID 10535737. S2CID 15288582.
  9. ^ a b c Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal of Cell Biology. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.
  10. ^ a b Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
  11. ^ Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
  12. ^ Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". The Journal of Biological Chemistry. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
  13. ^ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  14. ^ Horikawa HP, Kneussel M, El Far O, Betz H (Nov 2002). "Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin". Molecular and Cellular Neurosciences. 21 (3): 454–62. doi:10.1006/mcne.2002.1191. PMID 12498786. S2CID 54366866.

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC 103959. PMID 9882340.
  • Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". The Journal of Cell Biology. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
  • Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737. S2CID 15288582.
  • Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
  • Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
  • Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N (Nov 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. PMID 11106728. S2CID 18245989.
  • Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M (Mar 2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". Journal of Virology. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC 115924. PMID 11222723.
  • Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G (May 2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic". The EMBO Journal. 20 (9): 2191–201. doi:10.1093/emboj/20.9.2191. PMC 125242. PMID 11331585.
  • Takatsu H, Futatsumori M, Yoshino K, Yoshida Y, Shin HW, Nakayama K (Jun 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochemical and Biophysical Research Communications. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
  • Orzech E, Livshits L, Leyt J, Okhrimenko H, Reich V, Cohen S, Weiss A, Melamed-Book N, Lebendiker M, Altschuler Y, Aroeti B (Aug 2001). "Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins". The Journal of Biological Chemistry. 276 (33): 31340–8. doi:10.1074/jbc.M101054200. PMID 11418592.
  • Doray B, Kornfeld S (Jul 2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly". Molecular Biology of the Cell. 12 (7): 1925–35. doi:10.1091/mbc.12.7.1925. PMC 55640. PMID 11451993.
  • Shiba Y, Takatsu H, Shin HW, Nakayama K (Mar 2002). "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain". Journal of Biochemistry. 131 (3): 327–36. doi:10.1093/oxfordjournals.jbchem.a003107. PMID 11872161.
  • Austin C, Boehm M, Tooze SA (Apr 2002). "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3". Biochemistry. 41 (14): 4669–77. doi:10.1021/bi016064j. PMID 11926829.
  • Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M (Jul 2002). "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons". The Journal of Biological Chemistry. 277 (28): 25400–7. doi:10.1074/jbc.M110793200. PMID 11950833.
  • Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
  • Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Molecular Biology of the Cell. 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846.

External links

  • v
  • t
  • e
  • 1gyu: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1
    1gyu: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1
  • 1gyv: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1, L762E MUTANT
    1gyv: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1, L762E MUTANT
  • 1gyw: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1 A753D MUTANT
    1gyw: GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1 A753D MUTANT
  • 1iu1: Crystal structure of human gamma1-adaptin ear domain
    1iu1: Crystal structure of human gamma1-adaptin ear domain
  • 1w63: AP1 CLATHRIN ADAPTOR CORE
    1w63: AP1 CLATHRIN ADAPTOR CORE
  • 2a7b: On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data Collection Wavelength
    2a7b: On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data Collection Wavelength