ASB1

Protein-coding gene in the species Homo sapiens
ASB1
Identifiers
AliasesASB1, ASB-1, ankyrin repeat and SOCS box containing 1
External IDsOMIM: 605758; MGI: 1929735; HomoloGene: 9390; GeneCards: ASB1; OMA:ASB1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ASB1
Genomic location for ASB1
Band2q37.3Start238,426,742 bp[1]
End238,452,250 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ASB1
Genomic location for ASB1
Band1 D|1 46.19 cMStart91,468,266 bp[2]
End91,487,311 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • C1 segment

  • nucleus accumbens

  • right auricle

  • putamen

  • amygdala

  • left ventricle

  • hypothalamus

  • substantia nigra

  • caudate nucleus
Top expressed in
  • blood

  • otolith organ

  • utricle

  • seminiferous tubule

  • lumbar spinal ganglion

  • supraoptic nucleus

  • yolk sac

  • spermatocyte

  • substantia nigra

  • lumbar subsegment of spinal cord
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • ubiquitin protein ligase activity
Cellular component
  • cytosol
  • ubiquitin ligase complex
Biological process
  • multicellular organism development
  • intracellular signal transduction
  • male genitalia development
  • post-translational protein modification
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51665

65247

Ensembl

ENSG00000065802

ENSMUSG00000026311

UniProt

Q9Y576

Q9WV74

RefSeq (mRNA)

NM_001040445
NM_016114
NM_001330196

NM_001039126
NM_023046

RefSeq (protein)

NP_001035535
NP_001317125

NP_001034215
NP_075533

Location (UCSC)Chr 2: 238.43 – 238.45 MbChr 1: 91.47 – 91.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ankyrin repeat and SOCS box protein 1 is a protein that is in humans, encoded by the ASB1 gene.[5]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065802 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026311 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ASB1 ankyrin repeat and SOCS box-containing 1".

External links

Further reading

  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336. PMID 11509662.
  • Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene. 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


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