ATP5PO

Protein-coding gene in the species Homo sapiens
ATP5PO
Identifiers
AliasesATP5PO, ATPO, OSCP, HMC08D05, ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit, ATP synthase peripheral stalk subunit OSCP, ATP5O
External IDsOMIM: 600828; MGI: 106341; HomoloGene: 1283; GeneCards: ATP5PO; OMA:ATP5PO - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for ATP5PO
Genomic location for ATP5PO
Band21q22.11Start33,903,453 bp[1]
End33,915,814 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for ATP5PO
Genomic location for ATP5PO
Band16|16 C4Start91,722,102 bp[2]
End91,728,575 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ventricle

  • apex of heart

  • right auricle

  • ganglionic eminence

  • gastrocnemius muscle

  • mucosa of transverse colon

  • muscle of thigh

  • rectum

  • dorsolateral prefrontal cortex

  • body of stomach
Top expressed in
  • endocardial cushion

  • atrioventricular valve

  • myocardium of ventricle

  • muscle of thigh

  • intercostal muscle

  • yolk sac

  • soleus muscle

  • spermatocyte

  • right kidney

  • atrium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • proton-transporting ATP synthase activity, rotational mechanism
  • transmembrane transporter activity
  • transporter activity
  • ATPase activity
  • protein binding
Cellular component
  • mitochondrial proton-transporting ATP synthase complex
  • membrane
  • plasma membrane
  • mitochondrion
  • mitochondrial inner membrane
  • extracellular exosome
  • nucleus
  • extracellular matrix
Biological process
  • mitochondrial ATP synthesis coupled proton transport
  • ion transport
  • ATP synthesis coupled proton transport
  • ATP biosynthetic process
  • cristae formation
  • transport
  • proton transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

539

28080

Ensembl

ENSG00000241837

ENSMUSG00000022956

UniProt

P48047

Q9DB20

RefSeq (mRNA)

NM_001697

NM_138597

RefSeq (protein)

NP_001688

NP_613063

Location (UCSC)Chr 21: 33.9 – 33.92 MbChr 16: 91.72 – 91.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.[5]

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241837 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022956 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "ATP5PO ATP synthase peripheral stalk subunit OSCP [ Homo sapiens (human) ]".

External links

Further reading

  • Chen H, Morris MA, Rossier C, et al. (1996). "Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2". Genomics. 28 (3): 470–6. doi:10.1006/geno.1995.1176. PMID 7490082.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Aggeler R, Coons J, Taylor SW, et al. (2002). "A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies". J. Biol. Chem. 277 (37): 33906–12. doi:10.1074/jbc.M204538200. PMID 12110673.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Johnson KM, Chen X, Boitano A, et al. (2005). "Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423". Chem. Biol. 12 (4): 485–96. doi:10.1016/j.chembiol.2005.02.012. PMID 15850986.


  • v
  • t
  • e