Beta-Melanocyte-stimulating hormone

β-Melanocyte-stimulating hormone

Names
Other names beta-MSH, β-melanotropin, β-melanocortin, β-intermedin
Identifiers
CAS Number	17908-57-5
3D model (JSmol)	Interactive image
PubChem CID	16172929
CompTox Dashboard (EPA)	DTXSID00583247
SMILES CC(C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC=N3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NCC(=O)NC(CO)C(=O)N7CCCC7C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)O)N
Properties
Chemical formula	C118H174N34O35S
Molar mass	2660.95 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

β-Melanocyte-stimulating hormone (β-MSH) is an endogenous peptide hormone and neuropeptide.^[1] It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC).^[1] It is an agonist of the MC₁, MC₃, MC₄, and MC₅ receptors.^[1]

β-MSH is artificially generated because it does not exist in humans naturally.^{[contradictory][2]}

β-MSH is also known to decrease food intake in animals such as rats, chicken due to the effect of proopiomelanocortin (POMC).^[3] Research was performed to see the effect β-MSH has on chicks, and it has been found that chicks responded with a decrease in food and water intake when treated with β-MSH. The experiment showed that β-MSH causes anorexigenic effects in chicks.^[4]

See also

• α-Melanocyte-stimulating hormone
• γ-Melanocyte-stimulating hormone
• Adrenocorticotropic hormone

References

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