Calgranulin
Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils.
The proteins S100A8 and S100A9 form a heterodimer called calprotectin.
Human genes
- S100A8 (calgranulin A)
- S100A9 (calgranulin B)
- S100A12 (calgranulin C)
Function
Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations.[1] Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.
See also
- Measurement of faecal calprotectin
References
- ^ Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization". Am J Physiol. 275 (2 Pt 2): F255–61. doi:10.1152/ajprenal.1998.275.2.F255. PMID 9691016.
External links
- Calgranulin+A at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Calgranulin+B at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- v
- t
- e
Cell signaling: calcium signaling and calcium metabolism
Adhesion molecules | |
---|---|
Calcium channels | |
Calcium pumps | |
GPCRs | |
Annexins |
Second messengers | |
---|---|
Intracellular channels | |
Intracellular pumps | |
Sensors and chelators | |
Calcium-dependent chaperones | |
Calcium-dependent kinases | |
Calcium-dependent proteases | |
Indirect regulators |
Extracellular matrix proteins | |
---|---|
Secreted hormones |