Fluocinonide
Chemical compound
- C05AA11 (WHO) D07AC08 (WHO), QC05AA11 (WHO), QD07AC08 (WHO)
- 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
- 356-12-7
Y
- 9642
- 7078
- DB01047 Y
- 9265 Y
- 2W4A77YPAN
- D00325 Y
- ChEMBL1501 Y
- DTXSID8045307
- Interactive image
- O=C(OCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1[C@@H](F)C[C@@H]23)C)C)(C)C)C
- InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1Y
- Key:WJOHZNCJWYWUJD-IUGZLZTKSA-NY
Fluocinonide is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis.[3] It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.[3]
A common potential adverse effect is skin atrophy (thinning of the skin).[4]
In 2021, it was the 249th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[5][6]
Veterinary uses
Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs.[7] Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.[8]
References
- ^ "Fluocinonide Topical". MedlinePlus Drug Information. U.S. National Library of Medicine.
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
- ^ a b "Fluocinonide Topical: MedlinePlus Drug Information". medlineplus.gov. Retrieved 16 November 2022.
- ^ Jablonska S, Groniowska M, Dabroswki J (February 1979). "Comparative evaluation of skin atrophy in man induced by topical corticoids". The British Journal of Dermatology. 100 (2): 193–206. doi:10.1111/j.1365-2133.1979.tb05561.x. PMID 154921. S2CID 30656827.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Fluocinonide - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ^ Dog Allergies. Squidoo (Report).
- ^ Zenoble RD, Kemppainen RJ (September 1987). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs". Journal of the American Veterinary Medical Association. 191 (6): 685–688. PMID 2824410.
- v
- t
- e
- Antagonists: Aglepristone
- Ketoconazole
- Mifepristone
- Ulipristal acetate
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
- See also
- Glucocorticoid receptor modulators
- Mineralocorticoids and antimineralocorticoids
- List of corticosteroids
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