MEX3D

Protein-coding gene in the species Homo sapiens
MEX3D
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DGR

Identifiers
AliasesMEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D
External IDsOMIM: 611009; MGI: 2681847; HomoloGene: 16890; GeneCards: MEX3D; OMA:MEX3D - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MEX3D
Genomic location for MEX3D
Band19p13.3Start1,554,672 bp[1]
End1,568,325 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for MEX3D
Genomic location for MEX3D
Band10|10 C1Start80,216,189 bp[2]
End80,223,493 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • ganglionic eminence

  • ventricular zone

  • secondary oocyte

  • stromal cell of endometrium

  • C1 segment

  • mucosa of transverse colon

  • sural nerve

  • left ovary
Top expressed in
  • seminiferous tubule

  • hand

  • medial ganglionic eminence

  • mandibular prominence

  • maxillary prominence

  • superior cervical ganglion

  • spermatid

  • endocardial cushion

  • Gonadal ridge

  • Rostral migratory stream
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • nucleic acid binding
  • RNA binding
  • mRNA 3'-UTR AU-rich region binding
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • nucleus
Biological process
  • mRNA destabilization
  • mRNA localization resulting in posttranscriptional regulation of gene expression
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

399664

237400

Ensembl

ENSG00000181588

ENSMUSG00000048696

UniProt

Q86XN8

Q3UE17

RefSeq (mRNA)

NM_001174118
NM_203304

NM_198615

RefSeq (protein)

NP_001167589
NP_976049

NP_941017

Location (UCSC)Chr 19: 1.55 – 1.57 MbChr 10: 80.22 – 80.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.[5][6]

Function

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[6]

Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181588 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048696 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: mex-3 homolog D (C. elegans)".
  6. ^ a b c Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies". Nucleic Acids Res. 35 (4): 1289–300. doi:10.1093/nar/gkm016. PMC 1851655. PMID 17267406.


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