Mir-625 microRNA precursor family

mir-625
Identifiers
Symbol	mir-625
Rfam	RF01017
miRBase family	MIPF0000534
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-625 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. Many microRNAs play important roles in cancer development and progression.

mir-625 and gastric cancer

mir-625 has been shown to be down regulated in gastric cancers. This is important, as mir-625 is responsible for the regulation of metastasis in gastric tumour cells, and therefore downregulation of mir-625 results in increased metastasis.^[1] mir-625 is thought to act by inhibiting the ILK protein.^[1]

References

^ ^a ^b Wang M, Li C, Nie H, Lv X, Qu Y, Yu B, Su L, Li J, Chen X, Ju J, Yu Y, Yan M, Gu Q, Zhu Z, Liu B (July 2012). "Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK". FEBS Letters. 586 (16): 2382–8. doi:10.1016/j.febslet.2012.05.050. PMID 22677169.

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