RPA4

Protein-coding gene in the species Homo sapiens
RPA4
Identifiers
AliasesRPA4, HSU24186, replication protein A4
External IDsOMIM: 300767; HomoloGene: 88820; GeneCards: RPA4; OMA:RPA4 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for RPA4
Genomic location for RPA4
BandXq21.33Start96,883,908 bp[1]
End96,885,467 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • secondary oocyte

  • buccal mucosa cell

  • skin of hip

  • visceral pleura

  • parietal pleura

  • granulocyte

  • gonad

  • bone marrow

  • Achilles tendon
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • single-stranded DNA binding
  • DNA binding
  • damaged DNA binding
  • double-stranded DNA binding
  • protein binding
  • sequence-specific DNA binding
  • G-rich strand telomeric DNA binding
Cellular component
  • DNA replication factor A complex
  • nucleus
  • nucleoplasm
  • telomere
  • chromatin
  • condensed nuclear chromosome
  • site of double-strand break
Biological process
  • nucleotide-excision repair
  • DNA damage checkpoint signaling
  • DNA replication
  • DNA recombination
  • DNA replication initiation
  • nuclear DNA replication
  • DNA repair
  • cellular response to DNA damage stimulus
  • G1/S transition of mitotic cell cycle
  • telomere maintenance via recombination
  • double-strand break repair via homologous recombination
  • DNA topological change
  • DNA unwinding involved in DNA replication
  • base-excision repair
  • DNA mismatch repair
  • mitotic recombination
  • telomere maintenance via telomerase
  • reciprocal meiotic recombination
  • heteroduplex formation
  • positive regulation of helicase activity
  • regulation of DNA damage checkpoint
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29935

n/a

Ensembl

ENSG00000204086

n/a

UniProt

Q13156

n/a

RefSeq (mRNA)

NM_013347

n/a

RefSeq (protein)

NP_037479

n/a

Location (UCSC)Chr X: 96.88 – 96.89 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Replication protein A 30 kDa subunit is a protein that in humans is encoded by the RPA4 gene.[3][4]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204086 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Keshav KF, Chen C, Dutta A (Jun 1995). "Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex". Mol Cell Biol. 15 (6): 3119–28. doi:10.1128/mcb.15.6.3119. PMC 230543. PMID 7760808.
  4. ^ "Entrez Gene: RPA4 replication protein A4, 34kDa".

Further reading

  • Wu X, Yang Z, Liu Y, Zou Y (2006). "Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage". Biochem. J. 391 (Pt 3): 473–80. doi:10.1042/BJ20050379. PMC 1276948. PMID 15929725.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Parker A, Gu Y, Mahoney W, et al. (2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. 276 (8): 5547–55. doi:10.1074/jbc.M008463200. PMID 11092888.
  • Amacker M, Hottiger M, Mossi R, Hübscher U (1997). "HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase". AIDS. 11 (4): 534–6. PMID 9084803.
  • Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. 15 (10): 5396–402. doi:10.1128/mcb.15.10.5396. PMC 230789. PMID 7565690.


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