SLC22A13

Protein-coding gene in the species Homo sapiens
SLC22A13
Identifiers
AliasesSLC22A13, OAT10, OCTL1, OCTL3, ORCTL-3, ORCTL3, solute carrier family 22 member 13
External IDsOMIM: 604047; MGI: 2143107; HomoloGene: 3140; GeneCards: SLC22A13; OMA:SLC22A13 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SLC22A13
Genomic location for SLC22A13
Band3p22.2Start38,265,812 bp[1]
End38,278,757 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SLC22A13
Genomic location for SLC22A13
Band9|9 F3Start119,022,040 bp[2]
End119,038,164 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • kidney

  • renal cortex

  • stromal cell of endometrium

  • metanephros

  • blood

  • cerebellum

  • cerebellar cortex

  • gastrocnemius muscle

  • cerebellar hemisphere

  • prefrontal cortex
Top expressed in
  • kidney

  • proximal tubule

  • proximal straight tubule

  • morula

  • thyroid gland

  • proximal convoluted tubule

  • Greater petrosal nerve

  • right ventricle

  • ascending aorta

  • jejunum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transmembrane transporter activity
  • organic cation transmembrane transporter activity
  • nicotinate transmembrane transporter activity
  • inorganic anion exchanger activity
  • sodium-independent organic anion transmembrane transporter activity
Cellular component
  • integral component of plasma membrane
  • apical plasma membrane
  • membrane
  • extracellular exosome
  • integral component of membrane
  • plasma membrane
Biological process
  • nicotinate transport
  • transmembrane transport
  • urate transport
  • organic cation transport
  • NAD biosynthesis via nicotinamide riboside salvage pathway
  • inorganic anion transport
  • sodium-independent organic anion transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9390

102570

Ensembl

ENSG00000172940

ENSMUSG00000074028

UniProt

Q9Y226

Q6A4L0

RefSeq (mRNA)

NM_004256

NM_133980

RefSeq (protein)

NP_004247

NP_598741

Location (UCSC)Chr 3: 38.27 – 38.28 MbChr 9: 119.02 – 119.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene. [5]

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172940 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074028 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 22 member 13". Retrieved 2017-10-05.

Further reading

  • Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G (2008). "Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)". J. Biol. Chem. 283 (24): 16332–41. doi:10.1074/jbc.M800737200. PMID 18411268.
  • Irshad S, Mahul-Mellier AL, Kassouf N, Lemarie A, Grimm S (2009). "Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers". Cell Death Differ. 16 (6): 890–8. doi:10.1038/cdd.2009.21. PMC 2683172. PMID 19282870.
  • Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolić I, Koepsell H, Brockmöller J (2009). "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin". Clin. Pharmacol. Ther. 86 (3): 299–306. doi:10.1038/clpt.2009.92. PMID 19536068. S2CID 8583867.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Schulz C, Fork C, Bauer T, Golz S, Geerts A, Schömig E, Gründemann D (2014). "SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct". Biochem. J. 457 (2): 243–51. doi:10.1042/BJ20130654. PMID 24147638.
  • AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang MS, Qize D, Harding SV, Al-Rubaish A, Alzahrani AJ, Al-Ali A, Sanders TA, Aboagye EO, Grimm S (2015). "The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis". Oncogene. 34 (13): 1718–28. doi:10.1038/onc.2014.93. PMC 4119473. PMID 24769897.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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