SLC38A5

Protein-coding gene in the species Homo sapiens
SLC38A5
Identifiers
AliasesSLC38A5, JM24, SN2, SNAT5, pp7194, solute carrier family 38 member 5
External IDsOMIM: 300649; MGI: 2148066; HomoloGene: 24917; GeneCards: SLC38A5; OMA:SLC38A5 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SLC38A5
Genomic location for SLC38A5
BandXp11.23Start48,458,537 bp[1]
End48,470,260 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for SLC38A5
Genomic location for SLC38A5
BandX|X A1.1Start8,137,372 bp[2]
End8,146,418 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • bone marrow cells

  • stromal cell of endometrium

  • upper lobe of left lung

  • left lobe of thyroid gland

  • ganglionic eminence

  • right lobe of thyroid gland

  • hypothalamus

  • amygdala

  • prefrontal cortex
Top expressed in
  • cumulus cell

  • left lung lobe

  • blood

  • pyloric antrum

  • medial ganglionic eminence

  • entorhinal cortex

  • right lung

  • islet of Langerhans

  • epithelium of stomach

  • spleen
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • glycine transmembrane transporter activity
  • amino acid transmembrane transporter activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • amino acid transport
  • glycine transport
  • amino acid transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

92745

209837

Ensembl

ENSG00000017483

ENSMUSG00000031170

UniProt

Q8WUX1

Q3U1J0

RefSeq (mRNA)

NM_033518

NM_172479

RefSeq (protein)

NP_277053

NP_766067

Location (UCSC)Chr X: 48.46 – 48.47 MbChr X: 8.14 – 8.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 38 member 5 is a protein that in humans is encoded by the SLC38A5 gene. [5]

Function

The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000017483 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031170 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 38 member 5". Retrieved 2017-10-07.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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