STIM1

STIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K60, 3TEQ, 2MAJ, 2MAK, 4O9B
Identifiers
Aliases	STIM1, D11S4896E, GOK, IMD10, STRMK, TAM, TAM1, stromal interaction molecule 1
External IDs	OMIM: 605921; MGI: 107476; HomoloGene: 20681; GeneCards: STIM1; OMA:STIM1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 3,854,527 bp[1] End 4,093,210 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E2- E3|7 54.71 cM Start 101,917,013 bp[2] End 102,086,526 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle minor salivary glands stromal cell of endometrium popliteal artery left uterine tube gastric mucosa gallbladder skin of abdomen canal of the cervix right coronary artery Top expressed in extraocular muscle lip plantaris muscle spermatocyte extensor digitorum longus muscle lateral recess superior frontal gyrus esophagus sternocleidomastoid muscle soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding calcium channel regulator activity microtubule plus-end binding metal ion binding protease binding protein binding identical protein binding Cellular component cytoplasm integral component of membrane endoplasmic reticulum membrane membrane integral component of plasma membrane cortical endoplasmic reticulum sarcoplasmic reticulum integral component of endoplasmic reticulum membrane endoplasmic reticulum sarcoplasmic reticulum membrane microtubule cytoskeleton plasma membrane Biological process regulation of cardiac conduction regulation of calcium ion transport ion transport detection of calcium ion enamel mineralization activation of store-operated calcium channel activity calcium ion transport cellular calcium ion homeostasis regulation of store-operated calcium entry store-operated calcium entry positive regulation of angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6786 20866 Ensembl ENSG00000167323 ENSMUSG00000030987 UniProt Q13586 P70302 RefSeq (mRNA) NM_003156 NM_001277961 NM_001277962 NM_009287 NM_001374058 NM_001374060 NM_001400557 RefSeq (protein) NP_001264890 NP_001264891 NP_003147 NP_001369495 NP_001369496 NP_001369497 NP_001369498 NP_001369499 NP_001369500 NP_001369501 NP_001369502 NP_001369503 NP_001369504 NP_001369505 NP_001369506 NP_001369507 NP_001369508 NP_001369509 NP_001369510 NP_033313 NP_001360987 NP_001360989 NP_001387486 Location (UCSC) Chr 11: 3.85 – 4.09 Mb Chr 7: 101.92 – 102.09 Mb PubMed search [3] [4]
Wikidata
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Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene.^[5][6][7] STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane.^[8]

Even though the protein has been identified earlier, its function was unknown until recently. In 2005, it was discovered that STIM1 functions as a calcium sensor in the endoplasmic reticulum.^[9][10] Upon activation of the IP3 receptor, the calcium concentration in the endoplasmic reticulum decreases, which is sensed by STIM1, via its EF hand domain. STIM1 activates the "store-operated" ORAI1 calcium ion channels in the plasma membrane, via intracellular STIM1 movement, clustering under plasma membrane and protein interaction with ORAI isoforms.^[11][12][13] STIM1-mediated calcium entry is required for thrombin-induced disassembly of VE-cadherin adherens junctions.^[14] 2-Aminoethoxydiphenyl borate (2-APB) and 4-chloro-3-ethylphenol (4-CEP) cause STIM1 clustering in a cell and prevent STIM1 moving toward plasma membrane.^[15]

Interactions

STIM1 has been shown to interact with ORAI1, TMEM110 (STIMATE^[16]), SERCA, TMEM66 (SARAF), and STIM2.^[6]

Clinical relevance

STIM1 mutations are associated with Immunodeficiency 10, Tubular aggregate myopathy type 1 (TAM1), and Stormorken syndrome.^[17]

References