San Roque González de Santa Cruz

25°52′59″S 57°16′59″W / 25.883°S 57.283°W / -25.883; -57.283CountryParaguayDepartmentParaguaríFounded1538Founded byDomingo Martínez de IralaGovernment
 • Intendente MunicipalDel Pilar Cerafín Montiel SernaArea
 • Total293 km2 (113 sq mi)Population
 • Total11.648 (2,008) • Density40/km2 (100/sq mi)Area code(595)(535)

San Roque González de Santa Cruz is a distrito in the Paraguarí Department of Paraguay, it is located 97 km from Asunción, the capital of the country.

The National Route 1, crosses through this city.