TERF2IP

Protein-coding gene in the species Homo sapiens

TERF2IP

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1FEX, 3K6G, 4RQI

Identifiers

Aliases

TERF2IP, DRIP5, RAP1, TERF2 interacting protein

External IDs

OMIM: 605061; MGI: 1929871; HomoloGene: 10357; GeneCards: TERF2IP; OMA:TERF2IP - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q23.1	Start	75,647,773 bp^[1]
Band	16q23.1	End	75,761,872 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 E1	Start	112,738,030 bp^[2]
Band	8\|8 E1	End	112,747,160 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

Brodmann area 23

Pars compacta

pars reticulata

superior vestibular nucleus

pons

internal globus pallidus

lateral nuclear group of thalamus

Brodmann area 9

superior frontal gyrus

Top expressed in

ventromedial nucleus

supraoptic nucleus

paraventricular nucleus of hypothalamus

dorsomedial hypothalamic nucleus

lateral hypothalamus

ventral tegmental area

arcuate nucleus

dorsal tegmental nucleus

mammillary body

habenula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding telomeric DNA binding protein binding G-rich strand telomeric DNA binding phosphatase binding
Cellular component	nuclear telomere cap complex nuclear envelope chromosome shelterin complex telomere nuclear chromosome Mre11 complex nucleus nucleoplasm cytosol nuclear body cytoplasm
Biological process	negative regulation of DNA recombination at telomere telomere maintenance via telomerase protection from non-homologous end joining at telomere regulation of double-strand break repair via homologous recombination transcription, DNA-templated positive regulation of peptidyl-serine phosphorylation protein localization to chromosome, telomeric region positive regulation of protein acetylation telomere maintenance via telomere lengthening positive regulation of NF-kappaB transcription factor activity positive regulation of I-kappaB kinase/NF-kappaB signaling telomere maintenance telomere capping negative regulation of protein phosphorylation regulation of transcription, DNA-templated regulation of telomere maintenance negative regulation of telomere maintenance positive regulation of NIK/NF-kappaB signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54386


57321

Ensembl


ENSG00000166848


ENSMUSG00000033430

UniProt


Q9NYB0


Q91VL8

RefSeq (mRNA)


NM_018975


NM_020584

RefSeq (protein)


NP_061848


NP_065609

Location (UCSC)

Chr 16: 75.65 – 75.76 Mb

Chr 8: 112.74 – 112.75 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Telomeric repeat-binding factor 2-interacting protein 1 also known as repressor activator protein 1 (Rap1) is a protein that in humans is encoded by the TERF2IP gene.^[5]^[6]

Interactions

TERF2IP has been shown to interact with Ku80,^[7] Rad50^[7] and TERF2.^[5]^[7]^[8] Upon interaction, TERF2IP/TERF2 complex has been shown to bind to telomeric junction sites with higher affinity^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166848 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033430 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Li B, Oestreich S, de Lange T (May 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490. S2CID 7956545.
^ "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein".
^ ^a ^b ^c O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (July 2004). "The human Rap1 protein complex and modulation of telomere length". The Journal of Biological Chemistry. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. PMID 15100233.
^ Zhu XD, Küster B, Mann M, Petrini JH, de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nature Genetics. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888. S2CID 6689794.
^ Arat NÖ, Griffith JD (December 2012). "Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere". The Journal of Biological Chemistry. 287 (50): 41583–94. doi:10.1074/jbc.M112.415984. PMC 3516710. PMID 23086976.

Zhu XD, Küster B, Mann M, Petrini JH, de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nature Genetics. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888. S2CID 6689794.
Hanaoka S, Nagadoi A, Yoshimura S, Aimoto S, Li B, de Lange T, Nishimura Y (September 2001). "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains". Journal of Molecular Biology. 312 (1): 167–75. doi:10.1006/jmbi.2001.4924. PMID 11545594.
Loayza D, De Lange T (June 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. Bibcode:2003Natur.423.1013L. doi:10.1038/nature01688. PMID 12768206. S2CID 4370276.
Li B, de Lange T (December 2003). "Rap1 affects the length and heterogeneity of human telomeres". Molecular Biology of the Cell. 14 (12): 5060–8. doi:10.1091/mbc.E03-06-0403. PMC 284807. PMID 14565979.
Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T (December 2003). "ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes". Molecular Cell. 12 (6): 1489–98. doi:10.1016/S1097-2765(03)00478-7. PMID 14690602.
O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (July 2004). "The human Rap1 protein complex and modulation of telomere length". The Journal of Biological Chemistry. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. PMID 15100233.
Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (July 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449. S2CID 11543383.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T (November 2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres". The Journal of Biological Chemistry. 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID 15316005.
Liu D, O'Connor MS, Qin J, Songyang Z (December 2004). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins". The Journal of Biological Chemistry. 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID 15383534.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Antoine K, Ferbus D, Kolahgar G, Prospéri MT, Goubin G (July 2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". Journal of Cellular Biochemistry. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID 15838871. S2CID 10264323.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Wu Y, Zacal NJ, Rainbow AJ, Zhu XD (February 2007). "XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening". DNA Repair. 6 (2): 157–66. doi:10.1016/j.dnarep.2006.09.005. PMID 17055345.
Bae NS, Baumann P (May 2007). "A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends". Molecular Cell. 26 (3): 323–34. doi:10.1016/j.molcel.2007.03.023. PMID 17499040.
Cai Y, Kandula V, Kosuru R, Ye X, Irwin MG, Xia Z (Oct 2017). "Decoding telomere protein Rap1: its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy". Cell Cycle. 16 (19): 1765–1773. doi:10.1080/15384101.2017.1371886. PMC 5628636. PMID 28853973.
Cai Y, Liu H, Song E, Wang L, Xu J, He Y, Xia Z (Mar 2021). "Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling". Theranostics. 11 (10): 4710–4727. doi:10.7150/thno.51739. PMC 7978321. PMID 33754023.