Talastine
Chemical compound
- R06AB07 (WHO)
- 4-benzyl-2-[2-(dimethylamino)ethyl]phthalazin-1(2H)-one
- 16188-61-7
Y
- 65624
- 59065 Y
- 49AB2PA48B
- DTXSID20167265
- Interactive image
- O=C1c3ccccc3\C(=N/N1CCN(C)C)Cc2ccccc2
InChI
- InChI=1S/C19H21N3O/c1-21(2)12-13-22-19(23)17-11-7-6-10-16(17)18(20-22)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3Y
- Key:LCAAMXMULMCKLJ-UHFFFAOYSA-NY
Talastine (trade name Ahanon) is an antihistamine.[1]
Synthesis
The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with dimethylaminoethyl chloride.[2][3]
References
- ^ Richter G, Kühn E (1990). "[Talastine (Ahanon) as a cause of allergic drug exanthema]". Dermatologische Monatschrift (in German). 176 (2–3): 111–3. PMID 1973126.
- ^ DE 1046625, Engelbrecht, et al., issued 1958, assigned to VEB Deutsches Hydrierwerk Rodleben
- ^ US 3017411, Engelbrecht, et al., issued 1962, assigned to VEB Deutsches Hydrierwerk Rodleben
External links
- "Talastine". Comparative Toxicogenomics Database.
- Talastine at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Antihistamines (R06)
- Astemizole
- Azelastine
- Bilastine
- Emedastine
- Mizolastine
- Talastine
- Diarylmethoxyalkylamines: Bromazine (bromodiphenhydramine)
- Carbinoxamine
- Chlorphenoxamine
- Clemastine
- Diphenhydramine (+naproxen)
- Diphenylpyraline
- Doxylamine
- Ebastine
- Orphenadrine
- Diphenylmethylpiperazines: Buclizine
- Cetirizine
- Chlorcyclizine
- Cinnarizine
- Cyclizine
- Etodroxizine
- Hydroxyzine
- Meclizine
- Oxatomide
- Phenylpyridinylpropanamines: Brompheniramine
- Chlorphenamine
- Dexbrompheniramine (+pseudoephedrine)
- Dexchlorpheniramine (+betamethasone)
- Pheniramine
- Phenylpiperazines: Antidepressants (e.g., trazodone)
- Phenbenzamine
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