11-Ketoprogesteron
 | |
| Data klinikal | |
|---|---|
| Nama dagang | Ketogestin |
| Nama lain | Bio 66; U-1258; 11-Oksoprogesteron; Pregn-4-ena-3,11,20-trion |
| Pengecam | |
Nama IUPAC
| |
| Nombor CAS |
|
| PubChem CID |
|
| ChemSpider |
|
| UNII |
|
| ChEMBL |
|
| CompTox Dashboard (EPA) |
|
| ECHA InfoCard | 100.007.476  |
| Data kimia dan fizikal | |
| Formula | C21H28O3 |
| Jisim molar | 328.45 g·mol−1 |
| Model 3D (JSmol) |
|
SMILES
| |
InChI
| |
11-Ketoprogesteron atau 11-oksoprogesteron, juga dikenali sebagai pregn-4-ena-3,11,20-trion, ialah sejenis steroid pregnan (17β-etilandrostana) yang berkaitan dengan kortison (11-keto-17α, 21-dihydroxyprogesterone) yang sebelumnya digunakan dalam perubatan veterinar dalam rawatan ketosis Bovinae. Ia disintesis pada tahun 1940.[1] Steroid ini mempunyai kesan mendalam terhadap metabolisme karbohidrat dan mempunyai aktiviti dikaitkan dengan hormon korteks adrenal seperti kortison.[2] 11-Ketoprogesteron boleh bertindak melalui reseptor glukokortikoid membran.[3]
Rujukan
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. m/s. 1014–. ISBN 978-1-4757-2085-3.
- ^ Veterinary Medicine. American Veterinary Publishing Company. 1953.
Experimentally, it is reported that ketogestin has a profound effect upon carbohydrate metabolism, accelerating production of glucose from protein (gluconegenesis). It possesses physiological activities associated with certain hormones of the adrenal cortex. Its effect on carbohydrate metabolism is similar to that of cortisone, as proved by deposition of glycogen, increasing glycosuria, and decreasing fat metabolism. This compound, however, does not cause certain undesirable activities in ketosis and other conditions as do other adrenocortical hormones, in that it does not cause retention of the sodium ion, nor does it produce hypertension during high sodium ion intake. Ketogestin is devoid of androgenic, estrogenic, or progestational activity and is nontoxic in amounts greatly exceeding pharmacological dosage.
- ^ Harrison, R. W.; Balasubramanian, K.; Yeakley, J.; Fant, M.; Svec, F.; Fairfield, S. (1979). "Heterogeneity of AtT-20 Cell Glucocorticoid Binding Sites: Evidence for a Membrane Receptor". Steroid Hormone Receptor Systems. Advances in Experimental Medicine and Biology. 117. m/s. 423–440. doi:10.1007/978-1-4757-6589-2_23. ISBN 978-1-4757-6591-5. ISSN 0065-2598. PMID 474288.
- l
- b
- s
