CXCL9

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Hemokin (C-X-C motiv) ligand 9
Identifikatori
SimboliCXCL9; CMK; Humig; MIG; SCYB9; crg-10
Vanjski IDOMIM: 601704 MGI: 1352449 HomoloGene: 1813 GeneCards: CXCL9 Gene
Ontologija gena
Molekularna funkcija • aktivnost hemokina
Celularna komponenta • ekstracelularni region
• ekstracelularni prostor
Biološki proces • hemotaksa
• inflamatorni respons
• imunski respons
• ćelijski odbrambeni respons
• prenos signala
• signalni put, G-protein spregnuti receptor protein
• interćelijska signalizacija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez428317329
EnsemblENSG00000138755ENSMUSG00000029417
UniProtQ07325n/a
RefSeq (mRNA)NM_002416NM_008599
RefSeq (protein)NP_002407NP_032625
Lokacija (UCSC)Chr 4:
77.14 - 77.15 Mb		Chr 5:
93.4 - 93.4 Mb
PubMed pretraga[1][2]

CXCL9, hemokine (C-X-C motif) ligand 9, je mali citokin iz CXC hemokin familije. On je takođe poznat kao monokin indukovan gama interferonom (MIG). CXCL9 je T-ćelijski hemoatraktant. On je blisko srodan sa dva druga CXC hemokina: CXCL10 i CXCL11, čiji geni su locirani u blizini CXCL9 gena na ljudskom hromozomu 4.[1][2] CXCL9, CXCL10 i CXCL11 invršavaju svoje hemotaksne funkcije putem interakcija sa hemokin receptorom CXCR3.[3][4]

Interakcije

Za CXCL9 je bilo pokazano da ostvaruje interakcije sa CXCR3.[5][6]

Reference

  1. ↑ Lee HH, Farber JM (1996). „Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster"”. Cytogenet. Cell Genet. 74 (4): 255–8. DOI:10.1159/000134428. PMID 8976378. 
  2. ↑ O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39–42. DOI:10.1159/000015209. PMID 10343098. 
  3. ↑ Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)”. J. Invest. Dermatol. 112 (5): 716–22. DOI:10.1046/j.1523-1747.1999.00581.x. PMID 10233762. 
  4. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  5. ↑ Lasagni, Laura; Francalanci Michela, Annunziato Francesco, Lazzeri Elena, Giannini Stefano, Cosmi Lorenzo, Sagrinati Costanza, Mazzinghi Benedetta, Orlando Claudio, Maggi Enrico, Marra Fabio, Romagnani Sergio, Serio Mario, Romagnani Paola (June 2003). „An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4”. J. Exp. Med. (United States) 197 (11): 1537–49. DOI:10.1084/jem.20021897. ISSN 0022-1007. PMC 2193908. PMID 12782716. 
  6. ↑ Weng, Y; Siciliano S J, Waldburger K E, Sirotina-Meisher A, Staruch M J, Daugherty B L, Gould S L, Springer M S, DeMartino J A (July 1998). „Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors”. J. Biol. Chem. (UNITED STATES) 273 (29): 18288–91. DOI:10.1074/jbc.273.29.18288. ISSN 0021-9258. PMID 9660793. 

Dodatna literatura

  • Farber JM (1990). „A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.”. Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5238–42. DOI:10.1073/pnas.87.14.5238. PMC 54298. PMID 2115167. 
  • Liao F, Rabin RL, Yannelli JR, et al. (1995). „Human Mig chemokine: biochemical and functional characterization.”. J. Exp. Med. 182 (5): 1301–14. DOI:10.1084/jem.182.5.1301. PMC 2192190. PMID 7595201. 
  • Farber JM (1993). „HuMig: a new human member of the chemokine family of cytokines.”. Biochem. Biophys. Res. Commun. 192 (1): 223–30. DOI:10.1006/bbrc.1993.1403. PMID 8476424. 
  • Lee HH, Farber JM (1997). „Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster".”. Cytogenet. Cell Genet. 74 (4): 255–8. DOI:10.1159/000134428. PMID 8976378. 
  • Weng Y, Siciliano SJ, Waldburger KE, et al. (1998). „Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.”. J. Biol. Chem. 273 (29): 18288–91. DOI:10.1074/jbc.273.29.18288. PMID 9660793. 
  • Erdel M, Laich A, Utermann G, et al. (1998). „The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10).”. Cytogenet. Cell Genet. 81 (3-4): 271–2. DOI:10.1159/000015043. PMID 9730616. 
  • Jenh CH, Cox MA, Kaminski H, et al. (1999). „Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors.”. J. Immunol. 162 (7): 3765–9. PMID 10201891. 
  • Rabin RL, Park MK, Liao F, et al. (1999). „Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling.”. J. Immunol. 162 (7): 3840–50. PMID 10201901. 
  • Tensen CP, Flier J, Van Der Raaij-Helmer EM, et al. (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).”. J. Invest. Dermatol. 112 (5): 716–22. DOI:10.1046/j.1523-1747.1999.00581.x. PMID 10233762. 
  • Shields PL, Morland CM, Salmon M, et al. (1999). „Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver.”. J. Immunol. 163 (11): 6236–43. PMID 10570316. 
  • Jinquan T, Jing C, Jacobi HH, et al. (2000). „CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma.”. J. Immunol. 165 (3): 1548–56. PMID 10903763. 
  • Loetscher P, Pellegrino A, Gong JH, et al. (2001). „The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.”. J. Biol. Chem. 276 (5): 2986–91. DOI:10.1074/jbc.M005652200. PMID 11110785. 
  • Romagnani P, Annunziato F, Lazzeri E, et al. (2001). „Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus.”. Blood 97 (3): 601–7. PMID 11157474. 
  • Dwinell MB, Lügering N, Eckmann L, Kagnoff MF (2001). „Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells.”. Gastroenterology 120 (1): 49–59. DOI:10.1053/gast.2001.20914. PMID 11208713. 
  • Lambeir AM, Proost P, Durinx C, et al. (2001). „Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.”. J. Biol. Chem. 276 (32): 29839–45. DOI:10.1074/jbc.M103106200. PMID 11390394. 
  • Stoof TJ, Flier J, Sampat S, et al. (2001). „The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells.”. Br. J. Dermatol. 144 (6): 1114–20. DOI:10.1046/j.1365-2133.2001.04220.x. PMID 11422029. 
  • Campbell JD, Stinson MJ, Simons FE, et al. (2001). „In vivo stability of human chemokine and chemokine receptor expression.”. Hum. Immunol. 62 (7): 668–78. DOI:10.1016/S0198-8859(01)00260-9. PMID 11423172. 
  • Scapini P, Laudanna C, Pinardi C, et al. (2001). „Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19.”. Eur. J. Immunol. 31 (7): 1981–8. DOI:10.1002/1521-4141(200107)31:7<1981::AID-IMMU1981>3.0.CO;2-X. PMID 11449350. 
  • Gillitzer R (2001). „Inflammation in human skin: a model to study chemokine-mediated leukocyte migration in vivo.”. J. Pathol. 194 (4): 393–4. DOI:10.1002/1096-9896(200108)194:4<393::AID-PATH907>3.0.CO;2-7. PMID 11523044. 
  • Romagnani P, Rotondi M, Lazzeri E, et al. (2002). „Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves' disease.”. Am. J. Pathol. 161 (1): 195–206. PMC 1850693. PMID 12107104. 
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Po familiji
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poput IL-6/gp130 koristeći
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IL-12 familija
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Drugi
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CCL
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CXCL
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TNF (ligand) superfamilija
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alfa ( Pegilirani 2a, Pegilirani 2b), beta (1a, 1b)
DrugiPo funkciji
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)