FLT4

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Fms-srodna tirozinska kinaza 4
Dostupne strukture
4BSJ, 4BSK
Identifikatori
SimboliFLT4; FLT41; LMPH1A; PCL; VEGFR3
Vanjski IDOMIM: 136352 MGI: 95561 HomoloGene: 7321 GeneCards: FLT4 Gene
EC broj2.7.10.1
Ontologija gena
Molekulska funkcija aktivnost transmembranske receptorske proteinske tirozinske kinaze
aktivnost receptora aktiviranog vaskularnim endotelnim faktorom rasta
proteinsko vezivanje
Ćelijska komponenta ekstracelularni region
nukleus
citoplazma
Biološki proces pozitivna regulacija proteinske fosforilacije
pozitivna regulacija endotelne ćelijske proliferacije
vaskulaturno razviće
Ortolozi
VrstaČovekMiš
Entrez232414257
EnsemblENSG00000037280ENSMUSG00000020357
UniProtP35916P35917
Ref. Sekv. (iRNK)NM_002020NM_008029
Ref. Sekv. (protein)NP_002011NP_032055
Lokacija (UCSC)Chr 5:
180.03 - 180.08 Mb
Chr 11:
49.61 - 49.65 Mb
PubMed pretraga[1][2]

Fms-srodna tirozinska kinaza 4, takođe poznata kao FLT4, protein je koji je kod ljudi kodiran FLT4 genom.[1][2]

Ovaj gen kodira receptor tirozinske kinaze za vaskularne endotelne faktore rasta C i D. Smatra se da ovaj protein učestvuje u limfangiogenezi i održavanju limfhatičnog endotela. Mutacije ovog gena uzrokuju nasledni lomfedem tipa IA.[1]

Interakcije

FLT4 formira interakcije sa SHC1.[3][4][5]

Vidi još

  • VEGF receptori

Reference

  1. 1,0 1,1 „Entrez Gene: FLT4 fms-related tyrosine kinase 4”. 
  2. Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). „Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene”. Genomics 13 (2): 475–8. DOI:10.1016/0888-7543(92)90277-Y. PMID 1319394. 
  3. Pajusola, K; Aprelikova O; Pelicci G; Weich H; Claesson-Welsh L; Alitalo K (December 1994). „Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors”. Oncogene (ENGLAND) 9 (12): 3545–55. ISSN 0950-9232. PMID 7970715. 
  4. Fournier, E; Blaikie P; Rosnet O; Margolis B; Birnbaum D; Borg J P (January 1999). „Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling”. Oncogene (ENGLAND) 18 (2): 507–14. DOI:10.1038/sj.onc.1202315. ISSN 0950-9232. PMID 9927207. 
  5. Fournier, E; Rosnet O; Marchetto S; Turck C W; Rottapel R; Pelicci P G; Birnbaum D; Borg J P (May 1996). „Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase”. J. Biol. Chem. (UNITED STATES) 271 (22): 12956–63. DOI:10.1074/jbc.271.22.12956. ISSN 0021-9258. PMID 8662748. 

Literatura

  • Petrova TV, Makinen T, Alitalo K (1999). „Signaling via vascular endothelial growth factor receptors.”. Exp. Cell Res. 253 (1): 117–30. DOI:10.1006/excr.1999.4707. PMID 10579917. 
  • Aprelikova O, Pajusola K, Partanen J, et al. (1992). „FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.”. Cancer Res. 52 (3): 746–8. PMID 1310071. 
  • Galland F, Karamysheva A, Mattei MG, et al. (1992). „Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.”. Genomics 13 (2): 475–8. DOI:10.1016/0888-7543(92)90277-Y. PMID 1319394. 
  • Pajusola K, Aprelikova O, Korhonen J, et al. (1992). „FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.”. Cancer Res. 52 (20): 5738–43. PMID 1327515. 
  • Fournier E, Dubreuil P, Birnbaum D, Borg JP (1995). „Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.”. Oncogene 11 (5): 921–31. PMID 7675451. 
  • Pajusola K, Aprelikova O, Armstrong E, et al. (1993). „Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.”. Oncogene 8 (11): 2931–7. PMID 7692369. 
  • Pajusola K, Aprelikova O, Pelicci G, et al. (1994). „Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.”. Oncogene 9 (12): 3545–55. PMID 7970715. 
  • Galland F, Karamysheva A, Pebusque MJ, et al. (1993). „The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.”. Oncogene 8 (5): 1233–40. PMID 8386825. 
  • Fournier E, Rosnet O, Marchetto S, et al. (1996). „Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase.”. J. Biol. Chem. 271 (22): 12956–63. DOI:10.1074/jbc.271.22.12956. PMID 8662748. 
  • Lee J, Gray A, Yuan J, et al. (1996). „Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.”. Proc. Natl. Acad. Sci. U.S.A. 93 (5): 1988–92. DOI:10.1073/pnas.93.5.1988. PMC 39896. PMID 8700872. 
  • Kukk E, Lymboussaki A, Taira S, et al. (1997). „VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development.”. Development 122 (12): 3829–37. PMID 9012504. 
  • Achen MG, Jeltsch M, Kukk E, et al. (1998). „Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).”. Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548–53. DOI:10.1073/pnas.95.2.548. PMC 18457. PMID 9435229. 
  • Ferrell RE, Levinson KL, Esman JH, et al. (1999). „Hereditary lymphedema: evidence for linkage and genetic heterogeneity.”. Hum. Mol. Genet. 7 (13): 2073–8. DOI:10.1093/hmg/7.13.2073. PMID 9817924. 
  • Fournier E, Blaikie P, Rosnet O, et al. (1999). „Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling.”. Oncogene 18 (2): 507–14. DOI:10.1038/sj.onc.1202315. PMID 9927207. 
  • Karkkainen MJ, Ferrell RE, Lawrence EC, et al. (2000). „Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.”. Nat. Genet. 25 (2): 153–9. DOI:10.1038/75997. PMID 10835628. 
  • Irrthum A, Karkkainen MJ, Devriendt K, et al. (2000). „Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase.”. Am. J. Hum. Genet. 67 (2): 295–301. DOI:10.1086/303019. PMC 1287178. PMID 10856194. 
  • Wang JF, Zhang XF, Groopman JE (2001). „Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration.”. J. Biol. Chem. 276 (45): 41950–7. DOI:10.1074/jbc.M101370200. PMID 11553610. 
  • Baldwin ME, Roufail S, Halford MM, et al. (2001). „Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis.”. J. Biol. Chem. 276 (47): 44307–14. DOI:10.1074/jbc.M106188200. PMID 11574540. 
  • Walter JW, North PE, Waner M, et al. (2002). „Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.”. Genes Chromosomes Cancer 33 (3): 295–303. DOI:10.1002/gcc.10028. PMID 11807987. 

Vanjske veze

  • GeneReviews/NCBI/NIH/UW entry on Milroy Disease
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Receptori faktora rasta
EGFR • ERBB2 • ERBB3 • ERBB4
IGF1R • INSR • INSRR
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ROS1
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Nervni faktori rasta
niski afinitet/p75 - visok afinitet Trk (TrkA, TrkB, TrkC) - Cilijarni neurotrofni faktor
Somatomedin
CSF
Stem ćelijski faktor - Eritropoietin
TGF put
TGF-beta (1, 2) - Aktivin (1, 2) - Bone morfogenetski protein (1, 2)
Drugi
vidi isto Faktori rasta
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)