Supstituisani amfetamin
| Supstituisani amfetamin | |
|---|---|
| Klasa leka | |
 Skeleton racemskog amfetamina | |
| Identifikatori klase | |
| Hemijska klasa | Supstituisani derivati amfetamina |
| Na Vikipodacima | |
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| L-amfetamin | D-amfetamin |
Supstituisani amfetamini u klasa jedinjenja bazirana na amfetaminskoj strukturi;[1] to uključuje sva derivatna jedinjenja koja nastaju zamenom, ili supstitucijom, jednog ili više atoma vodonika u strukturi jezgra amfetamina sa supstituentima.[1][2][3][4] Jedinjenja u ovoj klasi obuhvataju različite farmakološke podklase, uključujući stimulante, empatogene i halucinogene, između ostalog.[2] Primeri supstituisanih amfetamina su amfetamin (sam),[1][2] metamfetamin,[1] efedrin,[1] katinon,[1] fentermin,[1] mefentermin,[1] tranilcipromin,[5] bupropion,[1] metoksifenamin,[1] selegilin,[1] amfepramon (dietilpropion),[1] pirovaleron,[1] MDMA (ekstazi) i DOM (STP).
Reference
- ^ а б в г д ђ е ж з и ј к л Hagel JM, Krizevski R, Marsolais F, Lewinsohn E, Facchini PJ (2012). „Biosynthesis of amphetamine analogs in plants”. Trends Plant Sci. 17 (7): 404—412. PMID 22502775. doi:10.1016/j.tplants.2012.03.004. „Substituted amphetamines, which are also called phenylpropylamino alkaloids, are a diverse group of nitrogen-containing compounds that feature a phenethylamine backbone with a methyl group at the α-position relative to the nitrogen (Figure 1). Countless variation in functional group substitutions has yielded a collection of synthetic drugs with diverse pharmacological properties as stimulants, empathogens and hallucinogens [3]. ... Beyond (1R,2S)-ephedrine and (1S,2S)-pseudoephedrine, myriad other substituted amphetamines have important pharmaceutical applications. The stereochemistry at the α-carbon is often a key determinant of pharmacological activity, with (S)-enantiomers being more potent. For example, (S)-amphetamine, commonly known as d-amphetamine or dextroamphetamine, displays five times greater psychostimulant activity compared with its (R)-isomer [78]. Most such molecules are produced exclusively through chemical syntheses and many are prescribed widely in modern medicine. For example, (S)-amphetamine (Figure 4b), a key ingredient in Adderall and Dexedrine, is used to treat attention deficit hyperactivity disorder (ADHD) [79]. ...
[Figure 4](b) Examples of synthetic, pharmaceutically important substituted amphetamines.” - ^ а б в Glennon RA (2013). „Phenylisopropylamine stimulants: amphetamine-related agents”. Ур.: Lemke TL, Williams DA, Roche VF, Zito W. Foye's principles of medicinal chemistry (7th изд.). Philadelphia, USA: Wolters Kluwer Health/Lippincott Williams & Wilkins. стр. 646—648. ISBN 9781609133450. „The simplest unsubstituted phenylisopropylamine, 1-phenyl-2-aminopropane, or amphetamine, serves as a common structural template for hallucinogens and psychostimulants. Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class (39).”
- ^ Lillsunde P, Korte T (март 1991). „Determination of ring- and N-substituted amphetamines as heptafluorobutyryl derivatives”. Forensic Sci. Int. 49 (2): 205—213. PMID 1855720. doi:10.1016/0379-0738(91)90081-s. CS1 одржавање: Формат датума (веза)
- ^ Custodio, Raly James Perez; Botanas, Chrislean Jun; Yoon, Seong Shoon; Peña, June Bryan de la; Peña, Irene Joy dela; Kim, Mikyung; Woo, Taeseon; Seo, Joung-Wook; Jang, Choon-Gon; Kwon, Yong Ho; Kim, Nam Yong (2017-11-01). „Evaluation of the Abuse Potential of Novel Amphetamine Derivatives with Modifications on the Amine (NBNA) and Phenyl (EDA, PMEA, 2-APN) Sites”. Biomolecules & Therapeutics (на језику: енглески). 25 (6): 578—585. ISSN 2005-4483. PMC 5685426
. PMID 29081089. doi:10.4062/biomolther.2017.141. - ^ Ulrich S, Ricken R, Adli M (2017). „Tranylcypromine in mind (Part I): Review of pharmacology”. European Neuropsychopharmacology. 27 (8): 697—713. PMID 28655495. S2CID 4913721. doi:10.1016/j.euroneuro.2017.05.007 .
Literatura
- Ghodse, Hamid (2002). Drugs and Addictive Behaviour. A Guide to Treatment. 3rd Edition. Cambridge University Press. стр. 501. ISBN 978-0-511-05844-8.
- Glennon, Richard A. (2008). „Neurobiology of Hallucinogens”. The American Psychiatric Publishing textbook of substance abuse treatment. American Psychiatric Publishing. ISBN 978-1-58562-276-4.
- Goldfrank, Lewis R.; Flomenbaum, Neal (2006). Goldfrank's Toxicologic Emergencies, 8th Edition. McGraw Hill. ISBN 978-0-07-147914-1.
- Katzung, Bertram G. (2009). Basic & clinical pharmacology. 11th edition. McGraw-Hill Medical. ISBN 978-0-07-160405-5. [мртва веза]
- Ledgard, Jared (2007). A Laboratory History of Narcotics. Volume 1. Amphetamines and Derivatives. Jared Ledgard. стр. 268. ISBN 978-0-615-15694-1.
- Schatzberg, Alan F.; Nemeroff, Charles B. (2009). The American Psychiatric Publishing Textbook of Psychopharmacology. The American Psychiatric Publishing. ISBN 978-1-58562-309-9.
- Snow, Otto (2002). Amphetamine syntheses. Thoth Press. ISBN 978-0-9663128-3-6.
- Veselovskaya NV, Kovalenko AE (2000). Drugs. Properties, effects, pharmacokinetics, metabolism. MA: Triada-X. ISBN 978-5-94497-029-9.
Spoljašnje veze
Медији везани за чланак Supstituisani amfetamin на Викимедијиној остави
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- р
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Ligandi 5-HT2 receptora | |||||||
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Ligandi 5-HT3, 5-HT4, 5-HT5, 5-HT6, i 5-HT7 receptora | |||||||||||
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Aminoindani: 5-IAI • AMMI • ETAI • MDAI • MDMAI • MMAI • TAI; Aminotetralini: 6-CAT • 8-OH-DPAT • MDAT • MDMAT; Oksazolini: 4-Metilaminoreks • Aminoreks • Klominoreks • Fluminoreks; Fenetilamini (takođe Amfetamini, Katinoni, Fentermini, itd): 2-Metil-MDA • 4-CAB • 4-FA • 4-FMA • 4-HA • 4-MTA • 5-APDB • 5-Metil-MDA • 6-APDB • 6-Metil-MDA • AEMMA • Amiflamin • BDB • BOH • Brefedron • Butilon • Hlorfentermin • Kloforeks • Amfepramon • Metamfepramon • DFMDA • DMA • DMMA • EBDB • EDMA • Etilon • Etoloreks • Fenfluramin (Deksfenfluramin) • Flefedron • IAP • IMP • Lofofin • MBDB • MDA • MDEA • MDHMA • MDMA • MDMPEA • MDOH • MDPEA • Mefedron • Metedron • Metilon • MMA • MMDA • MMDMA • MMMA • NAP • Norfenfluramin • 4-TFMA • pBA • pCA • pIA • PMA • PMEA • PMMA • TAP; Piperazini: 2C-B-BZP • 2-BZP • 3-MeOPP • BZP • DCPP • MBZP • mCPP • MDBZP • MeOPP • Mepiprazol • pCPP • pFPP • pTFMPP • TFMPP; Triptamini: 4-Metil-αET • 4-Metil-αMT • 5-CT • 5-MeO-αET • 5-MeO-αMT • 5-MT • αET • αMT • DMT • Triptamin (sam); Drugi: Indeloksazin • Tramadol • Viqualin |
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Normativna kontrola: Državne  |
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