60S ribosomal protein L27

Protein found in humans
RPL27
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5AJ0, 3J7R, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC

Identifiers
AliasesRPL27, L27, ribosomal protein L27
External IDsOMIM: 607526; MGI: 98036; HomoloGene: 105144; GeneCards: RPL27; OMA:RPL27 - orthologs
Gene ontology
Molecular function
  • structural constituent of ribosome
  • RNA binding
  • protein binding
Cellular component
  • cytosol
  • ribosome
  • membrane
  • focal adhesion
  • intracellular anatomical structure
  • cytosolic large ribosomal subunit
  • extracellular exosome
  • nucleus
  • extracellular matrix
  • cytoplasm
  • endoplasmic reticulum
  • rough endoplasmic reticulum
  • cytoplasmic side of rough endoplasmic reticulum membrane
  • ribonucleoprotein complex
Biological process
  • viral transcription
  • SRP-dependent cotranslational protein targeting to membrane
  • translational initiation
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • protein biosynthesis
  • rRNA processing
  • response to aldosterone
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6155

19942

Ensembl

ENSG00000131469

ENSMUSG00000063316

UniProt

P61353

P61358

RefSeq (mRNA)

NM_000988

NM_011289

RefSeq (protein)

NP_000979
NP_001336850
NP_001336851

NP_035419

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L27 is a protein that in humans is encoded by the RPL27 gene.[3][4]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L27E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[4]

References

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Jones KW, Chevrette M, Shapero MH, Fournier RE (Jun 1993). "Generation of region- and species-specific expressed gene probes from somatic cell hybrids". Nat Genet. 1 (4): 278–83. doi:10.1038/ng0792-278. PMID 1302024. S2CID 30900271.
  4. ^ a b "Entrez Gene: RPL27 ribosomal protein L27".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. Bibcode:1994Sci...266...66M. doi:10.1126/science.7545954. PMID 7545954.
  • Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–66. doi:10.1093/hmg/4.8.1259. PMID 7581362.
  • Gallagher RA, McClean PM, Malik AN (1994). "Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney". Biochim. Biophys. Acta. 1217 (3): 329–32. doi:10.1016/0167-4781(94)90295-x. PMID 8148381.
  • Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.

External links

  • Overview of all the structural information available in the PDB for UniProt: P61353 (60S ribosomal protein L27) at the PDBe-KB.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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