60S ribosomal protein L39

Protein found in humans
RPL39
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4V5Z, 4D5Y, 3J7O

Identifiers
AliasesRPL39, L39, RPL39P42, RPL39_23_1806, ribosomal protein L39
External IDsOMIM: 300899; MGI: 1914498; HomoloGene: 133571; GeneCards: RPL39; OMA:RPL39 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for RPL39
Genomic location for RPL39
BandXq24Start119,786,504 bp[1]
End119,791,630 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for RPL39
Genomic location for RPL39
BandX|X A3.3Start36,346,173 bp[2]
End36,349,055 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • ventricular zone

  • endometrium

  • granulocyte

  • left ovary

  • skin of abdomen

  • skin of leg

  • lactiferous gland

  • subcutaneous adipose tissue

  • right ovary
Top expressed in
  • yolk sac

  • ventricular zone

  • embryo

  • embryo

  • ganglionic eminence

  • lip

  • esophagus

  • uterus

  • duodenum

  • urinary bladder
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA binding
  • structural constituent of ribosome
Cellular component
  • ribosome
  • cytosol
  • intracellular anatomical structure
  • extracellular space
  • cytosolic large ribosomal subunit
  • polysomal ribosome
Biological process
  • SRP-dependent cotranslational protein targeting to membrane
  • innate immune response in mucosa
  • viral transcription
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • protein biosynthesis
  • rRNA processing
  • antimicrobial humoral immune response mediated by antimicrobial peptide
  • cytoplasmic translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6170

67248

Ensembl

ENSG00000198918

ENSMUSG00000079641

UniProt

P62891

P62892

RefSeq (mRNA)

NM_001000

NM_026055

RefSeq (protein)

NP_000991

NP_080331

Location (UCSC)Chr X: 119.79 – 119.79 MbChr X: 36.35 – 36.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L39 is a protein that in humans is encoded by the RPL39 gene.[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198918 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079641 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Otsuka S, Tanaka M, Saito S, Yoshimoto K, Itakura M (Sep 1996). "Molecular cloning of a cDNA encoding human ribosomal protein L39". Biochim Biophys Acta. 1308 (2): 119–21. doi:10.1016/0167-4781(96)00106-6. PMID 8764829.
  6. ^ a b "Entrez Gene: RPL39 ribosomal protein L39".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
  • Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
  • Tsui SK, Lee SM, Fung KP, et al. (1997). "Primary structures and sequence analysis of human ribosomal proteins L39 and S27". Biochem. Mol. Biol. Int. 40 (3): 611–6. doi:10.1080/15216549600201203. PMID 8908372. S2CID 7909023.
  • Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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