Piromidic acid
Chemical compound
- J01MB03 (WHO)
- 8-Ethyl-5-oxo-2-pyrrolidin-1-yl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
- 19562-30-2 Y
- 4855
- 4689
- 3I12WH4EWF
- D01431
- CHEBI:32019
- DTXSID4045424
- Interactive image
- CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCCC3)C(=O)O
InChI
- InChI=1S/C14H16N4O3/c1-2-17-8-10(13(20)21)11(19)9-7-15-14(16-12(9)17)18-5-3-4-6-18/h7-8H,2-6H2,1H3,(H,20,21)
- Key:RCIMBBZXSXFZBV-UHFFFAOYSA-N
Piromidic acid is a quinolone antibiotic.[1]
References
- ^ Minami S, Shono T, Matsumoto JI (1971). "Pyrido [2, 3-d] pyrimidine Antibacterial Agents. II. Piromidic Acid and Related Compounds". Chemical and Pharmaceutical Bulletin. 19 (7): 1426–1432. doi:10.1248/cpb.19.1426.
- v
- t
- e
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor | |||||||||
---|---|---|---|---|---|---|---|---|---|
Sulfonamides (DHPS inhibitor) |
| ||||||||
Combinations |
| ||||||||
Other DHPS inhibitors |
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)
1st generation |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
Fluoroquinolones |
| ||||||||
Newer non-fluorinated | |||||||||
Related (DG) |
inhibitors
Nitroimidazole derivatives | |
---|---|
Nitrofuran derivatives |
Rifamycins/ RNA polymerase | |
---|---|
Lipiarmycins |
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
This systemic antibiotic-related article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e