Sulfaperin
Chemical compound
- J01ED06 (WHO)
- 4-amino-N-(5-methylpyrimidin-2-yl)benzenesulfonamide
- 599-88-2 Y
- 68933
- 62158 Y
- W5E840UV9P
- D07240 Y
- CHEBI:131722
- DTXSID2057782
- Interactive image
- O=S(=O)(Nc1ncc(cn1)C)c2ccc(N)cc2
InChI
- InChI=1S/C11H12N4O2S/c1-8-6-13-11(14-7-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15) Y
- Key:DZQVFHSCSRACSX-UHFFFAOYSA-N Y
Sulfaperin (or sulfaperine) is a sulfonamide antibacterial.[1]
References
- ^ Elks J, Ganellin CR (1990). Dictionary of drugs: Chemical Data, Structures, and Bibliographies (First ed.). Dordrecht: Springer. p. 1129. ISBN 978-1-4757-2085-3.
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(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor | |||||||||
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Sulfonamides (DHPS inhibitor) |
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Combinations |
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Other DHPS inhibitors |
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)
1st generation | |||||||||
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Fluoroquinolones |
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Newer non-fluorinated | |||||||||
Related (DG) |
inhibitors
Nitroimidazole derivatives | |
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Nitrofuran derivatives |
Rifamycins/ RNA polymerase | |
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Lipiarmycins |
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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