Vesicular glutamate transporter 1

Protein-coding gene in the species Homo sapiens
SLC17A7
Identifiers
AliasesSLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDsOMIM: 605208; MGI: 1920211; HomoloGene: 113454; GeneCards: SLC17A7; OMA:SLC17A7 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SLC17A7
Genomic location for SLC17A7
Band19q13.33Start49,429,401 bp[1]
End49,442,360 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SLC17A7
Genomic location for SLC17A7
Band7|7 B3Start44,813,373 bp[2]
End44,825,566 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • superior frontal gyrus

  • Brodmann area 10

  • frontal pole

  • Region I of hippocampus proper

  • middle temporal gyrus

  • Brodmann area 46

  • dorsolateral prefrontal cortex

  • orbitofrontal cortex

  • cingulate gyrus

  • postcentral gyrus
Top expressed in
  • superior frontal gyrus

  • prefrontal cortex

  • piriform cortex

  • cerebellar cortex

  • hippocampus proper

  • primary motor cortex

  • subiculum

  • habenula

  • cerebellar vermis

  • amygdala
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • inorganic phosphate transmembrane transporter activity
  • sodium:inorganic phosphate symporter activity
  • extracellularly glutamate-gated chloride channel activity
  • symporter activity
  • L-glutamate transmembrane transporter activity
  • neurotransmitter transmembrane transporter activity
Cellular component
  • postsynapse
  • integral component of membrane
  • membrane
  • synaptic vesicle
  • plasma membrane
  • synapse
  • excitatory synapse
  • synaptic vesicle membrane
  • cerebellar mossy fiber
  • presynaptic active zone
  • cell junction
  • intracellular organelle
  • neuron projection
  • clathrin-sculpted glutamate transport vesicle membrane
  • cytoplasmic vesicle
  • integral component of synaptic vesicle membrane
Biological process
  • phosphate ion transport
  • synaptic transmission, glutamatergic
  • sodium-dependent phosphate transport
  • sodium ion transport
  • chloride transmembrane transport
  • ion transport
  • glutamate secretion
  • synaptic vesicle lumen acidification
  • brain development
  • long-term memory
  • excitatory postsynaptic potential
  • neurotransmitter transport
  • neural retina development
  • L-glutamate import
  • sequestering of neurotransmitter
  • sodium ion transmembrane transport
  • transmembrane transport
  • chemical synaptic transmission
  • neurotransmitter loading into synaptic vesicle
  • L-glutamate transmembrane transport
  • regulation of synaptic vesicle endocytosis
  • regulation of synapse structure or activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57030

72961

Ensembl

ENSG00000104888

ENSMUSG00000070570

UniProt

Q9P2U7

Q3TXX4

RefSeq (mRNA)

NM_020309

NM_182993

RefSeq (protein)

NP_064705

NP_892038

Location (UCSC)Chr 19: 49.43 – 49.44 MbChr 7: 44.81 – 44.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.[5][6][7]

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104888 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070570 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.
  6. ^ Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.
  7. ^ a b "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

Further reading

  • Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter". Science. 289 (5481): 957–60. Bibcode:2000Sci...289..957B. doi:10.1126/science.289.5481.957. PMID 10938000.
  • Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons". Nature. 407 (6801): 189–94. Bibcode:2000Natur.407..189T. doi:10.1038/35025070. hdl:11858/00-001M-0000-0012-F987-C. PMID 11001057. S2CID 4412622.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophrenia Research. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.
  • Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex". Neuroscience. 134 (1): 59–68. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236. S2CID 25943855.
  • Vinatier J, Herzog E, Plamont MA, et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis". J. Neurochem. 97 (4): 1111–25. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361. S2CID 3133505.
  • Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters". Protein Sci. 16 (9): 1819–29. doi:10.1110/ps.072944707. PMC 2206968. PMID 17660252.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
  • Na+/Ca2+ exchanger
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
  • Na+-dependent ascorbic acid transporter
(24):
  • Na+/(Ca2+-K+) exchanger
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
  • Vesicular glutamate transporter 1
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
  • basolateral iron transporter
SLC41–48
(41):
(42):
(43):
  • Na+-independent, system-L like amino-acid transporter
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter, Cotransporter
  • Na+/K+,Cl−
  • Na+/Pi3
  • Na+/Cl−
  • Na+/glucose
  • Na+/I−
  • Cl−/K+
Antiporter (exchanger)
  • Na+/H+
  • Na+/Ca2+
    • Na+/(Ca2+-K+) - Cl−/HCO−
      3       (Band 3)
  • Cl−-formate
  • Cl−-oxalate
see also solute carrier disorders
  • v
  • t
  • e
Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
  • BPTES
  • CB-839
  • DON
ASTTooltip Aspartate aminotransferase
  • 2-Amino-3-butenoic acid
  • AAOA
  • AMB
  • β-DL-Methylene-aspartate
  • Hydrazinosuccinate
ALTTooltip Alanine aminotransferase
  • β-Chloro-L-alanine
  • L-Cycloserine
  • Propargylglycine
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e